Monday, January 16, 2012

Cancer Cells Need More Sugar

Cancer cells are different from normal cells. Every normal cell in your body has programmed into its genetic material, a process called APOPTOSIS, that lets it live and multiply only so long and then it dies. For example, skin cells live 28 days and die; cells lining your mouth live 24-48 hours and die; and red blood cells live up to 120 days. Cancer cells lose their ability to die. They try to live forever and they kill by going from one type of tissue to invade another type of tissue and destroy it. For example, breast cancer cells can eventually spread to your brain or lungs. They replace and destroy these tissues, and you die because your brain or lungs are not able to work properly.

Cancer cells grow and multiply so rapidly that they need huge amounts of the sugar, glucose, to supply them with the energy necessary for growth. Let me explain why cancer cells need so much sugar.

HOW CELLS GET ENERGY: All cells get their energy from two major processes:
• glycolysis, and
• the Krebs Cycle.
Normal cells primarily use the Krebs Cycle for energy since it is more efficient and provides more energy. However, cancer cells do not use the Krebs Cycle well, and therefore must depend on glycolysis. Because they use this inefficient pathway for energy, cancer cells that have forgotten to die have an incredible increase in need for energy from the sugar, glucose. Since insulin drives sugar into cells, insulin and ILGF-1 (insulin-like growth factor-1) feed cancer cells glucose, encouraging them to grow and multiply.

CANCER CELLS USE GLYCOLYSIS: In the early 1920s, Otto Warburg demonstrated that cancer cells can live without oxygen by getting their energy from glycolysis. Since glycolysis uses the single sugar, glucose, for energy, cancer cells use tremendous amounts of glucose to grow. Since cancer cells depend on glucose for energy, anything that interferes with the body's normal use of glucose supplies more sugar to the growing cancer cells, which will increase growth of an existing cancer and risk for new cancers. This is one of the reasons why diabetes and excess weight increase risk for cancer (see the third report below).

MITOCHONDRIA: In every cell are from a few to hundreds of small areas called mitochondria. They provide energy for cells through the Krebs Cycle, which is far more efficient than glycolysis, the process that supplies energy inside cells but outside the mitochondria. All cells need functioning mitochondria, where the Krebs Cycle occurs, to have apoptosis. Cancer cells have defective mitochondria which forces them to use glycolysis for energy. Since cancer cells have defective mitochondria, and do not use the Krebs cycle effectively, they do not have apoptosis, so they live indefinitely and kill by invading and destroying normal cells.

A CURE FOR CANCER? Researchers today are trying to cure cancer by blocking glycolysis. This could force mitochondria to become active again and use the Krebs Cycle for energy so that the cells can stop being cancerous and regain apoptosis, their programmable cell death. The chemical dichloroacetic acid (DCA), which increases the chemical reactions of the Krebs cycle in mitochondria, has been shown to kill cancer cells in laboratory tests and in animals. Anything that activates or restores mitochondria can restart apoptosis and cause cancer cells to kill themselves. At the University of Alberta, Dr. Evangelos Michelakis is doing research on DCA. Another activator of mitochondria, 3-BrOP, is being studied at The University of Texas M. D. Anderson Cancer Center. 2-deoxyglucose (2-DG) is being used at Emory University School of Medicine, and lactate dehydrogenase A is being researched at Johns Hopkins University.

DIANA'S FATHER WORKED WITH KREBS: In the 1930's, my wife Diana's father, Donald Purdie, was a professor at Cambridge University in England and spent his career working with Nobel Prize winner, Hans Krebs (1900-1981) whose research group worked out most of the chemical reactions that supply energy for cells. Her father published with Hans Krebs.

In the early 1940s, the Germans bombed England daily. Donald Purdie accepted the professorship and chair of the Department of Chemistry at Raffles College in Singapore, to get away from the war in Europe. Diana was born in Singapore in January 1942. Two weeks later, the Japanese invaded Singapore and her father was taken prisoner. The Japanese killed this great academic, starving him to death while he was forced to do manual labor to build the Burma-Thai railroad.

Diana and her mother and brother escaped on a boat that arrived in Bombay six weeks later. They then came to the United States and her mother didn't learn of Donald's death until three years later.

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